5 Skincare Combinations You’re Probably Doing But Shouldn’t Be

From choosing the right moisturizer for your skin type to getting your makeup collection summer ready, finding the right skincare products and treatments can be a challenge. Procuring your beauty arsenal is just the first step, however! We must also consider how and when to use our carefully selected skincare products.

While the general rule of applying products from lightest to heaviest still applies (e.g., toner, serum, then moisturizer), a product’s formulation will determine what other products and treatments it can be combined with. Properly combining products can help prevent over-sensitizing your skin—over-sensitized skin may be more vulnerable to irritation and UV damage. Furthermore, understanding how your products work together (or don’t) will help you get the full benefit of their active ingredients.

1. Benzoyl Peroxide and Antioxidants

Source: Citrine Natural Skin

While the debate over the safety of benzoyl peroxide is never ceasing, BP is undeniably one of the most popular and affordable over-the-counter acne treatments. Benzoyl peroxide is an oxidant that produces phenyl radicals, a type of free-radical that kills acne bacteria.

Combining benzoyl peroxide with antioxidants, which fight free radicals, results in both products losing their effectiveness. In other words, the active ingredients cancel each other out. There is one exception, however. Benzoyl peroxide and resveratrol (an antioxidant found in the skin of grapes) do not completely get in each other’s way, making the combo a potent acne-fighter (according to a UCLA study).

2. Vitamin C and Exfoliating Acids Alpha Hydroxy Acid (AHA) and Beta Hydroxy Acid (BHA)

Source: Byrdie

A common concern about vitamin C (often listed as “l-ascorbic acid”) and exfoliating acids (such as AHA and BHA) is that the pH of the acids renders vitamin C inactive. Dermatologist Paula Begoun points out that this concern has roots in a 1990 study that was never successfully repeated and argues that layering skincare products with different pH requirements may actually be OK.

Even if pH isn’t an issue, dermatologist Joshua Zeichner suggests exfoliating acids may overpower vitamin C because it’s rather unstable. Because the efficacy of combining vitamin C and exfoliating acids is an ongoing debate among skincare specialists, it may be worth it to play it safe and space out your products, morning and night.

3. Alpha Hydroxy Acid (AHA) and Water

Source: Gal Meets Glam

AHA is a water-soluble acid, meaning it dissolves in water. For this reason, an AHA-containing cleanser may not be the smartest buy. If your cleanser contains AHA, leave the cleanser on your skin for at least one minute so the product has a chance to do its job (chemically exfoliate skin) before being rinsed off.

If you do want to include AHA in your skincare regimen, find and use it in serum form.

4. Probiotics and Antimicrobials

Source: Byrdie

Probiotics in topical skincare products are making a big splash–and with good reason. Although research on this treatment is still budding, regular use of topical probiotics has been associated with clearer, less inflamed skin and reduced instances of dermatitis. Probiotics are living bacteria, so we want to be careful about using any products that kill bacteria. Pay extra attention to the bacteria-busting ingredients in your anti-acne products. Common antimicrobials include tea tree oil, sulfur, and benzoyl peroxide. Essential oils containing limonene, a compound present in most citrus oils, also have strong antimicrobial action and shouldn’t be combined with probiotic-infused products.

5. Microdermabrasion (PMD) and Retinol

Source: Hot Beauty Health

Microdermabrasion (including personal microdermabrasion devices (PMD)) deeply exfoliates skin by using a combination of suction and a fine-grit crystal disc to slough off dead skin cells and improve the appearance of fine lines and hyperpigmentation. This treatment is more abrasive than the typical physical exfoliate (scrub).

Therefore it’s wise to avoid the use of retinol, which sensitizes skin, for the week prior to a microdermabrasion treatment. If your skin feels a bit tender after the treatment, continue to avoid retinol-containing products for a few days. Slowly reintroduce retinol into your skincare regime by alternating application days.

Are there any product combinations that you avoid? 

  • Ellie

    Desserts…cookies, tartlets, truffles, ice cream, etc etc

  • Lauren Ulrich

    Ugh. Oreos.

  • chips & salsa. they’re my weakness.

    • Elle Ramirez

      Ditto I can ALWAYS find an excuse for why I should eat chips and salsa…i mean they’re healthy because they’re potatoes and tomoatoes…right…right?

      • I’m the exact same. I DEVOUR chips and salsa. I try not to feel too guilty as I super load my chips with salsa and salsa is very low in calories but yea, I become like the chips and salsa monster when its around 🙂

    • Same! And once you start, you just can’t stop eating it.

  • Mac and cheese– the real kind or even the powdered cheese version… I will take either!

  • Caramel Cone Ice Cream…it can be freezing outside and I gotta have it.

  • $18968296

    Just one? Alright, let’s keep this broad. Candy.

  • Most any involving Chocolate. And the Mint Bars at Goddess and Grocer.

    • Kristi Klemm

      Oh god…(no) thanks for reminding me of those bars. 🙂

  • Kristi Klemm

    Pizza. Especially deep dish. After that, probably desserts of some kind.

  • A soft, warm, salty pretzel for sure. Whether it is from a street vendor, a mall booth, or the Target snack stand, I literally cannot walk away from one.

  • Amanda @ Once Upon a Recipe

    I have a really hard time saying no to anything sweet, especially chocolate.

  • Christina Warsheski

    french fries. if i even smell them i start drooling. it’s terrible ;p

  • Lindsey

    Cookies and brownies are my weaknesses! I love them both so much I can never say no. And maybe cheese too!

  • Pasta! I will eat most pasta dishes that are placed in front of me. For me, pasta is always a good idea.


  • JuliebW

    If I come across tiramisu on a menu, I have to order it!

  • Jaclyn

    Homemade chocolate chip cookies or regular ruffle chips

  • Ana Kamin

    Oh boy there are so many, chocolate, bolognese, cheese. Actually there are only few I don’t like. 😉

  • Sarah

    Pretzels! 🙂

  • Colleen

    Guac and tortilla chips.

  • Warm, salted chips and good, spicy salsa. Oh, and key lime pie.

  • Salmon. I could eat salmon in so many different ways—or even the same way—and never tire of it. In salads, on bagels, in sushi—you name it; I love it.

  • Sarah G

    Bagels w/ cream cheese. Tomato pie. Mozzarella cheese. So many 🙂

  • Kimberly

    A warm Creme Brulee is my absolute weakness…..mmmmmmmm

  • I can’t believe nobody has said BACON yet!! Give me a helping of bacon on any given day and we likely will be best friends forever.

  • Alyssa

    Potato chips. I love kettle baked barbeque ones!
    That and fries. I love chocolate but savory is a lot better.

  • desireecherisse

    Ice cream.

  • Cookies, cheese cake, red velvet cake, any dessert really!! It’s just so good!

  • Mine is potatoes.

  • Chocolate. It’s so cliche but it’s totally true.

  • Sweets-wise: the first thing that comes to mind is dark chocolate truffles rolled in cocoa powder. I could eat my weight in those.
    Savory-wise: anything with raw ahi tuna. I am an addict.

  • Just about anything that includes cheese. Cheese and crackers, grilled cheese, nachos, pizza. I could go on…

  • busyVP

    Carrot Cake. I actually avoid restaurants that I know have carrot cake. I am powerless over carrot cake and I they offer it I will get it – every time.

  • Shar

    Ice cream! I can eat ice cream all year LONG!!